August, 4 2020 – Biocare Medical LLC, a leading provider of innovative, automated immunohistochemistry (IHC) reagents and instrumentation, in collaboration with Bethyl Laboratories announces the release of a new rabbit monoclonal antibody, TIGIT [BLR047F] antibody for in vitro diagnostic (IVD) use in the qualitative identification of the TIGIT protein by immunohistochemistry (IHC) in formalin-fixed paraffin-embedded (FFPE) human tissues.
TIGIT plays an important role in transplantation tolerance and tumor immune surveillance. Several studies indicate that TIGIT exhibits a synergistic function with the PD-1/PD-L1 pathway in the inhibition of T cell proliferation. The use of TIGIT, in conjunction with other checkpoint receptors, such as PD-1, has shown to be a promising marker for immunotherapy.
“We are excited for the release of an IVD grade TIGIT [BL074F] antibody for clinical application; the Bethyl clone [BLR047F] has been shown to display high sensitivity and specificity based on our internal research,” said Dr. Jason Ramos, Vice President – Reagent Research and Development at Biocare Medical.
We believe that our new TIGIT IVD antibody will be a cost-effective IHC solution to the pharmaceutical and biotech research institutions requiring an IVD grade quality in early-stage research and companion diagnostics development.
TIGIT [BLR047F] is an IVD antibody available in a concentrate format to support titration by end-users as well as a ready-to-use predilute format. TIGIT [BLR047F] antibody is commercially available for immediate sale within the domestic US and European Union.
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